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    脂質體裝備

    Extru 25-20臺式脂質體擠出儀

    蘇州艾特森制藥設備有限公司主營脂質體擠出器,臺式脂質體擠出器,微流控,微流控芯片,LNP微流控系統,微流控制備儀,mRNA微流控,實驗型旋轉滅菌柜,SiRNA脂質體,mRNA脂質體,陽離子脂質體,脂質體制備,新冠疫苗脂質體,疫苗脂質體,核酸脂質體,擠出儀,雙螺桿熱熔擠出機,立式滅菌柜,高壓均質機,剪切機,公司位于蘇州工業園區,是一家自主研發、專業生產及銷售制藥裝備的科技生產型企業!

    Extru 25-20臺式脂質體擠出儀

    Desktop Liposome Extruder:Extru 25-20


    專利號:2018216111703



    2520E.jpg

    主要應用

    The main application


    阿霉素脂質體 

    Liposome doxorubicin


    兩性霉素 B 脂質體 

    Amphotericin B liposome


    紫杉醇脂質體

    Paclitaxel liposomes


    奧沙利鉑脂質體

    Oxaliplatin liposomes


    伊立替康脂質體

    Irinotecan liposome


    SiRNA 脂質體

    SiRNA liposome


    白蛋白紫杉醇納米粒

    Albumin paclitaxel nanoparticles


    核酸類脂質體 

    Nucleic acid liposome


    其他整粒脂質體樣品

    Other whole li posome samples


    擠出原理

    Technical features


    脂質體擠出的原理在于,通過一定的擠出動力源將脂質體樣品粒子進行擠壓,使其在一定壓力條件下通過 PC濾膜, 此壓力作為粒子過膜過程中的剪切力可使其達到粒徑控制的效果。不論形態、大小和分布都可得到極大改善。 


    The principle of liposome extrusion is that the particles of liposome sample are extruded by a certain extrusion power source to pass through the PC membrane under a certain pressure. The pressure acts as the shear force in the process of the particles passing through the membrane, which can achieve the effect of particle size control. The shape, size and distribubtion can be greatly improved.


    支撐板和濾板主要起到支撐濾膜的作用。 由于磷脂有一定的相變溫度,所以在擠出之前需要對擠出器夾套通入恒溫水進行預熱至一定溫度(50~60℃),且在使用過程中需保持在此溫度。通常的脂質體品種擠出之后粒徑能達到 100nm以下,PDI 能控制在 0.1 以下。


    The support plate and the filter plate mainly play the role of supporting the filter membrane.Because of phospholipids have certain phase change temperature before extrusion need access to extruder jacket thermostatic water preheated to a certain temperature (50 ~ 60 ℃), and needs to keep the temperature in the process of use.The particle size of the normal liposome can reach below 100nm after extrusion, and the PDI can be controlled below 0.1.


    動力源:氮氣

    Power source: nitrogen


    技術特征

    Technical features


    核心部件 The core components


    支撐板(SS316L不銹鋼)

    Support plate (SS316L stainless steel)


    濾板(SS316L不銹鋼)

    Filter plate (SS316L stainless steel)


    濾膜:PC材質(聚碳酸酯)

    Filter membrane :PC material (polycarbonate)


    密封系統:PU材質/聚四氟乙烯

    Sealing system: PU material/polytetrafluoroethylene


    溫控系統:夾套控溫水

    Temperature control system: jacket control warm water


    技術特點 Technical characteristics


    單次樣品量少

    Low sample consumption


    壓力高

    High extrusion pressure


    殘留量為"0"

    No residue


    無需手動操作

    No manual operation required


    全程可控溫

    Whole process temperature control


    所有部件包括“O”型圈,墊圈均通過FDA 認證 

    All parts including "O" rings, gaskets are FDA approved


    裝卸方便,便于清洗和滅菌 

    Easy loading and unloading, easy cleaning and sterilization


    所有數據可直接放大 

    All data can be directly amplified


    可用于高濃度樣品處理 

    Can be used for high concentration sample processing


    可放在潔凈室中使用,符合 GMP 標準 

    Can be used in a clean room, in line with GMP standards



    型號 MODEL

    Extru 25-20

    最高壓力 [Mpa] 

    The highest pressure[Mpa]

    25

    最終產品粒徑 [nm]

    Final product size [nm]

    50~1000

    單批處理量[ml]

    The Final product size[ml]

    0~20

    最高產品濃度[mg/ml]

    Maximum product concentration[mg/ml]

    200

    工作溫度范圍

    Operating temperature range

    5~80℃

    產品材質

    Product material

    SS316L

    直徑[mm]

    The diameter of

    25

    動力源類型
    Power source type

    Gas




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