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    脂質體裝備

    TLEx 罐體式脂質體擠出器

    蘇州艾特森制藥設備有限公司主營脂質體擠出器,臺式脂質體擠出器,微流控,微流控芯片,LNP微流控系統,微流控制備儀,mRNA微流控,實驗型旋轉滅菌柜,SiRNA脂質體,mRNA脂質體,陽離子脂質體,脂質體制備,新冠疫苗脂質體,疫苗脂質體,核酸脂質體,擠出儀,雙螺桿熱熔擠出機,立式滅菌柜,高壓均質機,剪切機,公司位于蘇州工業園區,是一家自主研發、專業生產及銷售制藥裝備的科技生產型企業!

    TLEx 罐體式脂質體擠出器

    TLEx Tank Liposome Extruder


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    主要應用

    ◆阿霉素脂質體 Doxorubicin liposome

    ◆ 兩性霉素 B 脂質體 Amphotericin B liposome

    ◆ 紫杉醇脂質體 Paclitaxel liposomes

    ◆ 奧沙利鉑脂質體 Oxaliplatin liposomes

    ◆ 伊立替康脂質體 Irinotecan liposome

    ◆ SiRNA 脂質體 SiRNA liposome

    ◆ 白蛋白紫杉醇納米粒 Albumin paclitaxel nanoparticles

    ◆ 核酸類脂質體  Nucleic acid liposome

    ◆ mRNA脂質體 mRNA  liposome

     

    擠出原理

    Extrusion Principle

    圖片 1.png

     

    擠出原理圖

    Extrusion schematic diagram

     

    ◆樣品經過水化形成脂質體后,一般會通過高壓均質或者超聲的方式對樣品進行初步均質處理,處理后樣品粒徑和分布都會有所提高,但往往還不能達到所需要的理想要求。此時,將均質后樣品由下圖中進料口進入,通過高壓氮氣將樣品從濾膜中擠出,擠出后的樣品粒徑和分布都會進一步提高。

    After the sample is hydrated to form liposomes, the sample is usually homogenized by high-pressure homogenization or ultrasonic wave. After treatment, the particle size and distribution of the sample will be improved, but it can not meet the desired requirements. At this time, the homogenized sample enters through the feed port in the figure below, and the sample is extruded from the filter membrane by high-pressure nitrogen. The particle size and distribution of the extruded sample will be further improved

    圖片 2.png

    支撐板

    Support plate

     

    ◆支撐板和濾板主要起到支撐濾膜的作用。 由于磷脂有一定的相變溫度,所以在擠出之前需要對擠出器夾套通入恒溫水進行預熱至一定溫度(如70℃),且在使用過程中需保持在此溫度。通常的脂質體品種擠出之后粒徑能達到 100nm以下,PDI 能控制在 0.1 以下。

    The supporting plate and filter plate mainly play the role of supporting the filter membrane. Since the phospholipid has a certain phase transition temperature, it is necessary to preheat the extruder jacket with constant temperature water before extrusion to a certain temperature (such as 70 ℃), which should be maintained in the process of use. After extrusion, the particle size of liposomes can reach below 100nm and PDI can be controlled below 0.1.

     

    ◆動力源:氮氣

    Power source: nitrogen

     

    技術特征

    Technical features

    ◆核心部件  The core components

    支撐板(SS316L不銹鋼)

    Support plate (SS316L stainless steel)

    濾板(SS316L不銹鋼)

    Filter plate (SS316L stainless steel)

    濾膜:PC材質(聚碳酸酯)

    Filter membrane :PC material (polycarbonate)

    密封系統:PU材質/聚四氟乙烯

    Sealing system: PU material/polytetrafluoroethylene

    溫控系統:夾套控溫

    Temperature control system: jacket temperature  control

     

    ◆技術特點 Technical characteristics

    所有部件包括“O”型圈,墊圈均通過FDA 認證 

    All parts including "O" rings, gaskets are FDA approved

    操作便捷,可重復使用 

    Easy to operate and reusable

    嚴格控制產品粒徑,可單次操作或循環操作 

    Strictly control the particle size of products, single operation or cycle operation

    裝卸方便,便于清洗和滅菌 

    Easy loading and unloading, easy cleaning and sterilization

    所有數據可直接放大 

    All data can be directly amplified

    預設壓力保護閥 

    Preset pressure protection valve

    可用于高濃度樣品處理 

    Can be used for high concentration sample processing

    可放在潔凈室中使用,符合 GMP 標準 

    Can be used in a clean room, accord with GMP standards

     

    技術參數

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